To maximize patient safety while managing therapeutic outcome and effect, International Cardio Corporation (ICC) developed the HIFU SynthesizerTM Pre-CE Mark medical device proven in pre-clinical testing to image, target and non-invasively ablate tissue with sub-millimeter precision. ICC is a privately-held company with an initial vision to develop a non-invasive modality for the treatment of Peripheral Vascular Disease (PVD) using High-Frequency Focused Ultrasound (HIFU). The company was founded in 2009, then under the name Dutch Cardio.